Adaptogens

Ashwagandha KSM-66®

KSM-66® Ashwagandha (Withania somnifera) root extract ≥5% withanolides

KSM-66® ASHWAGANDHA (WITHANIA SOMNIFERA) ROOT EXTRACT ≥5% WITHANOLIDES. The world's most clinically researched ashwagandha, with 50+ gold-standard studies conducted across stress, sleep, cognition, and physical performance, published in PubMed-indexed peer-reviewed journals. A traditionally celebrated Ayurvedic herb, made exclusively from the root with no leaf content, and a natural addition to your daily wellness routine.

Benefits

Which ingredient is VitaMine using for this active? KSM-66 Ashwagandha (Withania somnifera) highest concentration, full-spectrum, root only extract: the world's most clinically researched & certified ashwagandha.

Our Experts' choice

Personal daily dose just for you, with microgram precision
Vegan, gluten-free, dairy-free
100% natural, pure roots of Withania somnifera- KSM-66 branded extract, ≥5% Withanolides
Does not contain leaves (withaferin A)
No artificial aromas or preservatives
Microgranule technology: protection of active ingredients, more effective absorption, tasteless
Controlled release, optimized bioavailability
Backed by 50+ gold-standard clinical trials and 45+ quality certifications

Why does it matter?

Not all ashwagandha is equal. KSM-66 is the highest-concentration, full-spectrum root-only extract on the market, produced by Ixoreal Biomed: the only ashwagandha maker to own its entire supply chain, from 1,500 acres of company-owned farms to the finished extract. Every batch is traceable, third-party certified (USDA Organic, Non-GMO, Informed Ingredient, and 40+ more), and manufactured under WHO-GMP and FSSC 22000 standards.

VitaMine chose KSM-66 specifically because its formulation excludes leaves, avoiding withaferin A, and because every efficacy claim behind it is supported by randomized, double-blind, placebo-controlled studies published in PubMed-indexed journals. With over 8 billion doses sold across 4,000+ products in 53 countries, it is the most trusted ashwagandha ingredient globally.

Effects

KSM-66 Ashwagandha is a 100% natural adaptogen with a rich history in Ayurvedic medicine. Its key bioactive compounds (Withanolides) have been extensively studied in human clinical trials across stress, cognition, sleep, energy, and hormonal health.

ADAPTOGENIC PROPERTIES FOR STRESS MANAGEMENT
KSM-66 is the most clinically validated ashwagandha for stress. Multiple randomized, double-blind, placebo-controlled trials have demonstrated significant reductions in perceived stress scores and serum cortisol levels at 600 mg/day. These studies follow the gold standard of evidence: conducted on healthy populations and published in peer-reviewed journals.

SUPERIOR POTENCY WITH A CLEAN EXTRACT
With a concentration of ≥5% Withanolides derived exclusively from the root, KSM-66 delivers the active compounds responsible for ashwagandha's benefits without contamination from leaf-derived compounds. This full-spectrum root profile preserves the synergistic phytochemical balance that makes the extract both effective and safe, confirmed by comprehensive toxicology studies with a NOAEL established at 2,000 mg/kg.

MULTIFACETED HEALTH BENEFITS
Incorporating KSM-66 into your wellness routine may offer benefits including:

Stress and anxiety management
Support for cognitive function, memory, and executive performance
Improved sleep quality and sleep onset
Enhanced energy levels and physical vitality
Hormonal balance support

Potential mood and emotional well-being benefits.

Ensure you consult with a healthcare professional to determine your specific needs and to discuss any supplementation.

Sources

If you want to know more:

Chandrasekhar et al., 2012: A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine, 34(3), 255–262. https://doi.org/10.4103/0253-7176.106022
Choudhary, D. et al., 2017: Efficacy and Safety of Ashwagandha Root Extract in Improving Memory and Cognitive Functions. Journal of Dietary Supplements, 14(6), 599–612. https://doi.org/10.1080/19390211.2017.1284970
Langade, D. et al., 2019: Efficacy and Safety of Ashwagandha Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study. Cureus, 11(9), e5797. https://doi.org/10.7759/cureus.5797
Wankhede, S. et al., 2015: Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. Journal of the International Society of Sports Nutrition, 12, 43. https://doi.org/10.1186/s12970-015-0104-9
Full list of 50+ KSM-66 clinical studies: https://ksm66ashwagandhaa.com/science.php